WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Gap junction       ID:04540
C=90; O=6; E=0.53; R=11.23; rawP=1.69e-05; adjP=0.0012
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152086 NA TUBA3E tubulin, alpha 3e 112714 ENSG00000152086
2  ENSG00000075886 NA TUBA3D tubulin, alpha 3d 113457 ENSG00000075886
3  ENSG00000188229 NA TUBB4B tubulin, beta 4B class IVb 10383 ENSG00000188229
4  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934
5  ENSG00000088256 NA GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2767 ENSG00000088256
6  ENSG00000127824 NA TUBA4A tubulin, alpha 4a 7277 ENSG00000127824


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=18; E=6.71; R=2.68; rawP=0.0002; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000117592 NA PRDX6 peroxiredoxin 6 9588 ENSG00000117592
2  ENSG00000166311 NA SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 6609 ENSG00000166311
3  ENSG00000204310 NA AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) 10554 ENSG00000204310
4  ENSG00000095380 NA NANS N-acetylneuraminic acid synthase 54187 ENSG00000095380
5  ENSG00000116096 NA SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 6697 ENSG00000116096
6  ENSG00000158467 NA AHCYL2 adenosylhomocysteinase-like 2 23382 ENSG00000158467
7  ENSG00000160688 NA FLAD1 FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) 80308 ENSG00000160688
8  ENSG00000100605 NA ITPK1 inositol-tetrakisphosphate 1-kinase 3705 ENSG00000100605
9  ENSG00000106992 NA AK1 adenylate kinase 1 203 ENSG00000106992
10  ENSG00000186184 NA POLR1D polymerase (RNA) I polypeptide D, 16kDa 51082 ENSG00000186184
11  ENSG00000093010 NA COMT catechol-O-methyltransferase 1312 ENSG00000093010
12  ENSG00000101444 NA AHCY adenosylhomocysteinase 191 ENSG00000101444
13  ENSG00000256269 NA HMBS hydroxymethylbilane synthase 3145 ENSG00000256269
14  ENSG00000185000 NA DGAT1 diacylglycerol O-acyltransferase 1 8694 ENSG00000185000
15  ENSG00000111666 NA CHPT1 choline phosphotransferase 1 56994 ENSG00000111666
16  ENSG00000106628 NA POLD2 polymerase (DNA directed), delta 2, accessory subunit 5425 ENSG00000106628
17  ENSG00000128309 NA MPST mercaptopyruvate sulfurtransferase 4357 ENSG00000128309
18  ENSG00000103876 NA FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2184 ENSG00000103876


Database:KEGG pathway       Name:Endocytosis       ID:04144
C=201; O=7; E=1.19; R=5.87; rawP=0.0002; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000063245 NA EPN1 epsin 1 29924 ENSG00000063245
2  ENSG00000101421 NA CHMP4B charged multivesicular body protein 4B 128866 ENSG00000101421
3  ENSG00000161203 NA AP2M1 adaptor-related protein complex 2, mu 1 subunit 1173 ENSG00000161203
4  ENSG00000197959 NA DNM3 dynamin 3 26052 ENSG00000197959
5  ENSG00000175416 NA CLTB clathrin, light chain B 1212 ENSG00000175416
6  ENSG00000067606 NA PRKCZ protein kinase C, zeta 5590 ENSG00000067606
7  ENSG00000079805 NA DNM2 dynamin 2 1785 ENSG00000079805


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=6; E=0.82; R=7.32; rawP=0.0002; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000172531 NA PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 5499 ENSG00000172531
2  ENSG00000078061 NA ARAF v-raf murine sarcoma 3611 viral oncogene homolog 369 ENSG00000078061
3  ENSG00000142208 NA AKT1 v-akt murine thymoma viral oncogene homolog 1 207 ENSG00000142208
4  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934
5  ENSG00000137312 NA FLOT1 flotillin 1 10211 ENSG00000137312
6  ENSG00000067606 NA PRKCZ protein kinase C, zeta 5590 ENSG00000067606


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=6; E=0.80; R=7.49; rawP=0.0002; adjP=0.0029
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103266 NA STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 10273 ENSG00000103266
2  ENSG00000108106 NA UBE2S ubiquitin-conjugating enzyme E2S 27338 ENSG00000108106
3  ENSG00000079999 NA KEAP1 kelch-like ECH-associated protein 1 9817 ENSG00000079999
4  ENSG00000107341 NA UBE2R2 ubiquitin-conjugating enzyme E2R 2 54926 ENSG00000107341
5  ENSG00000114125 NA RNF7 ring finger protein 7 9616 ENSG00000114125
6  ENSG00000185651 NA UBE2L3 ubiquitin-conjugating enzyme E2L 3 7332 ENSG00000185651


Database:KEGG pathway       Name:Pathogenic Escherichia coli infection       ID:05130
C=56; O=4; E=0.33; R=12.03; rawP=0.0003; adjP=0.0036
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152086 NA TUBA3E tubulin, alpha 3e 112714 ENSG00000152086
2  ENSG00000075886 NA TUBA3D tubulin, alpha 3d 113457 ENSG00000075886
3  ENSG00000188229 NA TUBB4B tubulin, beta 4B class IVb 10383 ENSG00000188229
4  ENSG00000127824 NA TUBA4A tubulin, alpha 4a 7277 ENSG00000127824


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=6; E=0.98; R=6.13; rawP=0.0005; adjP=0.0051
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103266 NA STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 10273 ENSG00000103266
2  ENSG00000167671 NA UBXN6 UBX domain protein 6 80700 ENSG00000167671
3  ENSG00000159461 NA AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 267 ENSG00000159461
4  ENSG00000136026 NA CKAP4 cytoskeleton-associated protein 4 10970 ENSG00000136026
5  ENSG00000138073 NA PREB prolactin regulatory element binding 10113 ENSG00000138073
6  ENSG00000179262 NA RAD23A RAD23 homolog A (S. cerevisiae) 5886 ENSG00000179262


Database:KEGG pathway       Name:Cysteine and methionine metabolism       ID:00270
C=36; O=3; E=0.21; R=14.04; rawP=0.0013; adjP=0.0117
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101444 NA AHCY adenosylhomocysteinase 191 ENSG00000101444
2  ENSG00000128309 NA MPST mercaptopyruvate sulfurtransferase 4357 ENSG00000128309
3  ENSG00000158467 NA AHCYL2 adenosylhomocysteinase-like 2 23382 ENSG00000158467


Database:KEGG pathway       Name:Phagosome       ID:04145
C=153; O=5; E=0.91; R=5.51; rawP=0.0023; adjP=0.0184
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000187240 NA DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 79659 ENSG00000187240
2  ENSG00000152086 NA TUBA3E tubulin, alpha 3e 112714 ENSG00000152086
3  ENSG00000075886 NA TUBA3D tubulin, alpha 3d 113457 ENSG00000075886
4  ENSG00000188229 NA TUBB4B tubulin, beta 4B class IVb 10383 ENSG00000188229
5  ENSG00000127824 NA TUBA4A tubulin, alpha 4a 7277 ENSG00000127824


Database:KEGG pathway       Name:Endometrial cancer       ID:05213
C=52; O=3; E=0.31; R=9.72; rawP=0.0037; adjP=0.0266
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000078061 NA ARAF v-raf murine sarcoma 3611 viral oncogene homolog 369 ENSG00000078061
2  ENSG00000142208 NA AKT1 v-akt murine thymoma viral oncogene homolog 1 207 ENSG00000142208
3  ENSG00000126934 NA MAP2K2 mitogen-activated protein kinase kinase 2 5605 ENSG00000126934




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).